Cities served nonstop from MKE
| Appleton, WI | ATW | Midwest |
| Atlanta, GA | ATL | AirTran, Delta, Midwest |
| Baltimore, MD | BWI | AirTran, Midwest* |
| Boston, MA | BOS | AirTran**, Midwest |
| Cancun/Rivera Maya, Mexico | CUN | Apple Vacations, Funjet Vacations*** |
| Charlotte, NC | CLT | US Airways |
| Chicago O'Hare, IL | ORD | American, United |
| Cincinnati, OH | CVG | Delta |
| Cleveland, OH | CLE | Continental, Midwest |
| Columbus, OH | CMH | Midwest |
| Cozumel, Mexico | CZM | Apple Vacations, Funjet Vacations*** |
| Dallas/Fort Worth, TX | DFW | American, Midwest |
| Dayton, OH | DAY | Midwest |
| Denver, CO | DEN | Frontier, Midwest, United |
| Des Moines, IA | DSM | Midwest |
| Detroit, MI | DTW | Northwest |
| Flint, MI | FNT | Midwest |
| Fort Lauderdale/Hollywood, FL | FLL | AirTran, Midwest* |
| Fort Myers, FL | RSW | AirTran |
| Grand Rapids, MI | GRR | Midwest |
| Green Bay, WI | GRB | Midwest |
| Hartford, CT | BDL | Midwest (Ending service on 9/8/2008) |
| Houston Intercontinental, TX | IAH | Continental |
| Indianapolis, IN | IND | Midwest |
| Ixtapa/Zihuatanejo, Mexico | ZIH | Apple Vacations, Funjet Vacations*** |
| Montego Bay, Jamaica | MBJ | Apple Vacations, Funjet Vacations*** |
| Kansas City, MO | MCI | Midwest |
| Las Vegas, NV | LAS | AirTran, Midwest |
| Los Angeles, CA | LAX | AirTran**, Midwest*, Northwest |
| Louisville, KY | SDF | Midwest (Ending service on 9/8/2008) |
| Madison, WI | MSN | Midwest |
| Manistee, MI | MBL | Great Lakes |
| Marquette, MI | MQT | American |
| Memphis, TN | MEM | Northwest |
| Minneapolis, MN | MSP | Midwest, Northwest |
| Muskegon, MI | MKG | Midwest (Ending service on 9/8/2008) |
| Nashville, TN | BNA | Midwest |
| New York La Guardia, NY | LGA | AirTran, Midwest |
| New York Newark, NJ | EWR | Continental, Midwest |
| Omaha, NE | OMA | Midwest |
| Orlando, FL | MCO | AirTran, Midwest |
| Philadelphia, PA | PHL | Midwest, US Airways |
| Phoenix, AZ | PHX | Midwest, US Airways |
| Pittsburgh, PA | PIT | Midwest |
| Puerto Vallarta, Mexico | PVR | Apple Vacations, Funjet Vacations*** |
| Punta Cana, Dominican Republic | PUJ | Apple Vacations, Funjet Vacations*** |
| Raleigh/Durham, NC | RDU | Midwest (Ending service on 9/8/2008) |
| Rhinelander, WI | RHI | Great Lakes |
| St. Louis, MO | STL | American, Midwest* |
| San Diego, CA | SAN | AirTran (Ending service on 9/3/2008) |
| San Francisco, CA | SFO | AirTran**, Midwest* |
| Seattle/Tacoma, WA | SEA | AirTran**, Midwest* |
| Tampa, FL | TPA | AirTran, Midwest |
| Toronto, ON | YYZ | Air Canada, Midwest |
| Washington, DC | DCA | AirTran**, Midwest |
| Wausau, WI | CWA | Midwest (Ending service on 9/8/2008) |
* Midwest Airlines nonstop service ending 9/8/2008, will continue one-stop service
** AirTran Airways nonstop service ending 9/3/2008, will continue one-stop service
*** Seasonal charter service, check operator schedule for dates